منابع مشابه
Exploring public genomics data for population pharmacogenomics
Racial and ethnic differences in drug responses are now well studied and documented. Pharmacogenomics research seeks to unravel the genetic underpinnings of inter-individual variability with the aim of tailored-made theranostics and therapeutics. Taking into account the differential expression of pharmacogenes coding for key metabolic enzymes and transporters that affect drug pharmacokinetics a...
متن کاملStatistical analysis of big data on pharmacogenomics.
This paper discusses statistical methods for estimating complex correlation structure from large pharmacogenomic datasets. We selectively review several prominent statistical methods for estimating large covariance matrix for understanding correlation structure, inverse covariance matrix for network modeling, large-scale simultaneous tests for selecting significantly differently expressed genes...
متن کاملFDA seeks genome-based drug data.
ingly high. Nearly 4 in 10 adults in Botswana and Swaziland are infected with the virus. China, India, Indonesia, and Russia are threatened by a new wave of HIV spread, mostly through injecting drug use and unprotected sex. In Eastern Europe and Central Asia, where an estimated 1.5 million individuals are living with HIV, the most severely affected areas are the Russian Federation, Ukraine, and...
متن کاملPharmacogenomics.
Pharmacogenomics, a revolutionary chapter in the history of pharmacology, has received new impetus from the development and accessibility of molecular biotechnologies, notably DNA chips. The longstanding notion of responders/non-responders has given way to a more organic approach, where idiosyncrasy becomes an obsolete concept. This is a major step towards predictive, individualized medicine. I...
متن کاملPharmacogenomics approach in psychiatry disorders
Psychiatric disorders are important health issues in the world, and their management is facing some serious challenges. Drugs that are widely used in the treatment of psychiatric disorders, including antidepressants, antipsychotics, and mood stabilizers, are often associated with many side effects and are adequately effective only in a small proportion of patients. Many factors, including genet...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 2004
ISSN: 0091-6765,1552-9924
DOI: 10.1289/ehp.112-1316888